TOPLINE:
Antidepressants usually are not related to an elevated danger for dementia, accelerated cognitive decline, or atrophy of white and grey matter in adults with no indicators of cognitive impairment, new analysis suggests.
METHODOLOGY:
- Investigators studied 5511 people (58% girls; imply age, 71 years) from the Rotterdam research, an ongoing potential population-based cohort research.
- Individuals have been free from dementia at baseline, and incident dementia was monitored from baseline till 2018 with repeated cognitive assessments utilizing the Mini-Psychological Standing Examination (MMSE) and the Geriatric Psychological Schedule, in addition to MRIs.
- Data on contributors’ antidepressant use was extracted from pharmacy information from 1992 till baseline (2002-2008).
- Throughout a imply follow-up of 10 years, 12% of contributors developed dementia.
TAKEAWAY:
- Total, 17% of contributors had used antidepressants in the course of the roughly 10-year interval previous to baseline, and 4.1% have been nonetheless utilizing antidepressants at baseline.
- Remedy use at baseline was extra frequent in girls than in males (21% vs 18%), and use elevated with age: From 2.1% in contributors aged between 45 and 50 years to 4.5% in these older than 80 years.
- After adjustment for confounders, there was no affiliation between antidepressant use and dementia danger (hazard ratio [HR], 1.14; 95% CI, 0.92-1.41), accelerated cognitive decline, or atrophy of white and grey matter.
- Nevertheless, tricyclic antidepressant use was related to elevated dementia danger (HR, 1.36; 95% CI, 1.01-1.83) in contrast with using selective serotonin reuptake inhibitors (HR, 1.12; 95% CI, 0.81-1.54).
IN PRACTICE:
“Though prescription of antidepressant treatment in older people, particularly these with some cognitive impairment, might have acute symptomatic anticholinergic results that warrant consideration in medical follow, our outcomes present that long-term antidepressant use doesn’t have lasting results on cognition or mind well being in older adults with out indication of cognitive impairment,” the authors wrote.
SOURCE:
Frank J. Wolters, MD, of the Division of Epidemiology and the Division of Radiology and Nuclear Medication and Alzheimer Heart, Erasmus College Medical Heart, Rotterdam, the Netherlands, was the senior creator on this research that was revealed on-line on April 1 in Alzheimer’s and Dementia.
LIMITATIONS:
Limitations included the priority that though exclusion of contributors with MMSE < 26 at baseline prevented reversed causation (ie, antidepressant use in response to melancholy in the course of the prodromal section of dementia), it might have launched choice bias by disregarding the consequences of antidepressant use previous to baseline and excluding contributors with decrease schooling.
DISCLOSURES:
This research was performed as a part of the Netherlands Consortium of Dementia Cohorts, which receives funding within the context of Deltaplan Dementie from ZonMW Memorabel and Alzheimer Nederland. Additional funding was additionally obtained from the Stichting Erasmus Trustfonds. This research was additional supported by a 2020 NARSAD Younger Investigator Grant from the Mind & Habits Analysis Basis. The authors reported no conflicts of curiosity or related monetary relationships.
