The Red Devils head to Snapdragon Stadium in San Diego looking to bounce back from a high-profile 2-1 loss to Arsenal in Los Angeles on Saturday that saw early goalscorer Rasmus Hojlund injured along with new signing Leny Yoro.
They will hope to get back to winning ways against Betis, who finished seventh in LaLiga last season.
Coached by former Manchester City and West Ham boss Manuel Pellegrini, they were edged out by Liverpool in Pittsburgh on Friday night as a result of Dominik Szoboszlai’s first-half goal having thrashed Austria Salzburg 5-1 in their opening friendly of the summer.
How to watch Manchester United vs Real Betis
TV channel and live stream: Manchester United vs Real Betis is available to watch live for subscribers via MUTV, with kick-off at 3am BST in the early hours of Thursday morning – 7pm local time.
Live blog: Follow tonight’s game live with Standard Sport’s dedicated match blog.