Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperon-mediated autophagy

Proceedings of the National Academy of Sciences, Volume 121, Issue 50, December 2024. <br/>SignificanceTargeting autophagy has shown increasing promise in the treatment of various diseases. While exploring the biological functions of indole terpenoids, we identified hapalindole Q as a mechanistically intriguing macroautophagy inhibitor, which …



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