The C-terminal activating domain promotes pannexin 1 channel opening

Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. <br/>SignificanceSignaling metabolites, such as adenosine triphosphate (ATP), are released through membrane channels to effectively clear dying cells in the body. Pannexin 1 (Panx1) serves as such a signal releaser and plays a pivotal role in immune response. …



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