Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants

Proceedings of the National Academy of Sciences, Volume 121, Issue 51, December 2024. <br/>SignificanceThe latest atomic resolution structures of KCNQ channels feature a narrow cavity region not sufficiently wide to accommodate fully hydrated K+ions. The mechanism of K+permeation through this constriction and the functional impact of the …



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