Structural basis for TIR domain–mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM

Proceedings of the National Academy of Sciences, Volume 122, Issue 2, January 2025. <br/>SignificanceThis study elucidates the structural basis of Toll-like receptor (TLR) signaling through the TIR domain–containing adaptor proteins TRIF and TRAM. By using cryoelectron microscopy (cryo-EM) and X-ray crystallography, we provide structural …



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